“Healthy” whole grains: What the evidence really shows

You hear about them all the time: those nutritious whole grains you should be eating every day if your goals include being slim and healthy — and whose goals don’t include that?

Do whole grains live up to their reputation as a superfood? Let’s take a closer look at the scientific evidence behind the claims made about their benefits. Then you can decide whether you need a daily dose of grains in your diet or not.

Disclaimer: The beneficial effects of whole grains on human health are well accepted in the medical and nutrition communities with significant support from the scientific literature. However, some evidence exists calling into question these beneficial effects.1 While studies show whole grains are better than refined grains for many health outcomes, there is almost a complete lack of research on whether whole grains are better than no grains. Therefore we question if their health benefits apply equally to all individuals, especially since many of the potentially beneficial components of whole grains can be obtained from other foods.

This guide is our attempt at summarizing what is known. It is written for adults who are concerned about whole grain intake and health.

Discuss any lifestyle changes with your doctor. Full disclaimer

First, what are whole grains?

Technically, whole grains are the seeds of cereal grasses. In their natural “whole” state, grains have a hard, inedible husk that covers three edible parts:

  • Bran: fiber
  • Germ: contains some B vitamins, minerals, fat, and protein
  • Endosperm: major portion of the grain; mainly starch with a small amount of protein, vitamins and minerals

Nutritionally speaking, whole grains have had their outer inedible husks removed but retain all three edible parts of the seed. By contrast, refined grains like white flour (including unbleached wheat flour) and white rice have their bran and germ removed during milling, leaving only the endosperm.

Most whole grains have some processing. For instance, whole wheat is ground or crushed to create whole-wheat flour; old-fashioned oats are steamed and rolled in order to make them more palatable and easier to digest.

Wild grains appear to have been eaten by hunter-gatherers in certain regions during the paleolithic era, including the areas known today as Southern Italy and Africa.2 During the Agricultural Revolution, larger quantities of wheat, barley, rice and other grains were grown and became a part of the human diet in many other areas.

Since then, people around the world have consumed a variety of grains based on cultural preferences and availability. Among the dozens of types of whole grains that exist, some of the most well-known and widely consumed include:

  • Barley
  • Brown rice
  • Bulgur
  • Corn
  • Oats
  • Rye
  • Whole wheat
  • Wild rice

According to the Whole Grains Council, the most commonly consumed whole grains in the US are whole wheat, oats, and brown rice.

Buyer beware: over the past several decades, the term whole grains has become a buzzword among the health conscious. Knowing this, manufacturers often include bold, eye-catching messages like “Contains 14 grams of whole grains” on boxes of cereal, whole-wheat pasta, granola bars and similar products, which often contain high levels of added sugar.

In fact, a 2013 review of more than 500 grain-based products found that those displaying a “whole grains” stamp contained more sugar — and were more expensive — than similar products without the stamp.3

Nutrition in whole grains

Are whole grains really a nutrient-packed energy source? That depends what we compare them to. While some types contain a bit more protein and micronutrients than others, they aren’t necessarily nutrient-rich when considered in the context of their carbohydrate and calorie content.4

For instance, a 40g (1/4 cup) serving of steel-cut oats — often suggested as an ideal meal to start your day — provides about 10 grams of protein (although this is considered “incomplete” protein since it lacks some of the essential amino acids), 8 grams of fiber (daily recommendations are around 30 grams per day), and about 10-20% of daily thiamin, iron, magnesium, biotin, selenium and zinc requirements. However, it also contains about 46 to 48 grams of net carbs and 150 calories, even when prepared without milk, fruit, sweeteners or other additives (compare that to the recommended less than 20 grams of net carbs for very low carbohydrate diets, and less than 50 for low carb diets).

How about using two slices of whole wheat bread to build your sandwich at lunch? This would provide about 8 grams of (incomplete) protein, a quarter of your daily selenium needs, and small amounts of thiamin, niacin, and magnesium, which would come with approximately 180 calories, 35 grams of net carbs and a comparably low 6 grams of fiber.

Brown rice’s nutritional profile is similar to that of whole wheat bread and oats, although even lower in protein and fiber.

Additionally, newly popular grains like quinoa and farro are often lauded for being higher in protein and fiber than rice or pasta. While this may be true, they too are relatively high in net carbs, meaning that you’d need to eat a number of portions a day (and a lot of carbs!) to meet micronutrient requirements. For people who would like to follow a lower carbohydrate way of eating, there are more suitable ways of getting the vitamins and minerals you need.

Whole grains contain phytonutrients, which are compounds found in plants that might potentially help protect cells from damage and reduce inflammation in the body. However, higher-quality studies are needed to confirm this.5

At the moment, we don’t know enough about phytonutrients to make them a priority for inclusion in our diets. In any case, many plant-derived foods contain these phytonutrients including olives, nuts and even oils. Therefore, it’s not necessary to eat whole grains to get these potentially beneficial compounds if that doesn’t suit your dietary pattern

And that leads us to the quality of the existing research on whole grains and health.

Whole-grain research: weak evidence overall

Studies about whole grains seem to receive more than their fair share of media coverage. One such study to make recent international news headlines was a series of systematic reviews and meta-analyses exploring the health effects of different types of carbohydrate, which was published in The Lancet early in 2019.

After analyzing 185 observational studies and 58 clinical trials, researchers concluded that eating more whole grains and fiber might be an effective strategy for preventing obesity, heart disease, diabetes, cancer, and reducing risk of early death.6

We wrote about that study when it came out, noting that it compared diets with whole grains to diets full of highly-refined grains.7 (We also addressed the erroneous myth that low-carb diets are necessarily low-fiber diets. They are not!) And we wondered aloud how the results would have been different if the comparison group ate a low-carb, no grain diet.

Diet Doctor: A low-carb diet does not mean a low-fiber diet

Importantly, the evidence for whole grains’ beneficial health effects are largely based on epidemiological or observational studies. This kind of evidence cannot prove cause and effect and we should not rely upon these studies to draw any firm conclusions.

Learn more about observational vs. experimental studies:

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Guide to observational vs. experimental studies

Guide In this guide, we discuss the differences between observational and experimental studies, the advantages and disadvantages of each.

Since whole grains are promoted as a healthy product – they are typically chosen and eaten by people who prioritize health – so these people not only eat whole grains, they tend to engage in a whole host of healthy behaviors too – like not smoking, eating lots of fruit and vegetables, and exercising. Thus, the association between whole-grain consumption and good health is a perfect example of the “healthy user bias.”

Take the example of the “Blue Zones,” sections of society where people live to be 100 years old far more frequently than the general population. They are reported to eat lots of whole grains. But we don’t know if they are healthier because of the whole grains or because they tend to practice many other health-conscious behaviors like exercising regularly, drinking alcohol in moderation, avoiding sugar-sweetened beverages and cooking fresh food at home on a regular basis.

Observational studies are also limited by “social desirability bias.” This is where people taking part in a study respond in a certain way in order to please the researchers.8 Since whole grains are promoted as healthy for us, many people may respond, “Yes, of course, every day!” to the question “Do you eat wholegrain bread?”— even when they prefer white bread! This makes it harder to rely on self-reported dietary intake of healthy foods.

How do we understand this better? Let’s examine the higher-quality randomized control trial (RCT) evidence to see how well it supports the claim that whole grains can improve your health.

RCTs are designed to compare an intervention (such as consuming more whole grains) with a control (consuming refined grains or a standard diet). In these whole grain RCT studies, we need to know what the whole grains were compared to. Did they compare eating whole grains to eating refined grains? Or was it a standard diet? Or even better, low-carb vegetables? As you will see, it makes a difference.

Whole grains and weight loss

Many nutrition authorities, including the Dietary Guidelines for Americans, keep sharing this message: “Eating plenty of whole grains, as part of an overall healthy diet, may help with weight management.”9 But how strong is the evidence linking high whole-grain intake and weight loss?

A 2013 systematic review of RCTs — considered the strongest type of evidence — found slightly higher fat loss (less than 0.5% difference) with no difference in overall weight loss in groups who consumed diets high in whole grains compared to groups who consumed refined grains.10 A newer systematic review published in 2019 found no weight loss benefit from whole-grain consumption.11

In other words, RCTs show the effect of whole grains on weight loss to be small at best. However, some studies show beneficial effects beyond just weight loss.

Several RCT studies have found that among normal weight and overweight adults, those who consumed whole grains compared to refined grains for four to 16 weeks experienced greater increases in resting metabolic rate and greater decreases in belly fat, insulin resistance, inflammation and body weight.12

In one study, people who ate whole rye products had greater fat loss compared to those who consumed refined grains. The same was not found for wholegrain wheat.13

Bottom line: RCTs show that adding whole grains to the diet has minimal benefit on body weight. However, replacing refined grains with whole grains likely has more significant benefits. Therefore it is likely that some of the benefit of eating more whole grains comes from eating less refined grains, in addition to small, if any, beneficial effects of the whole grains themselves.

Whole grains and diabetes

Can eating whole grains on a regular basis help prevent type two diabetes and blood sugar spikes?

Once again, observational trials show a relationship between eating whole grains and having a lower risk of developing type 2 diabetes. However, we have already reviewed the weakness in this level of data and explained how it does not prove a beneficial effect from whole grains. How does the claim hold up under scrutiny of higher quality randomized controlled trials (RCTs)?

A randomized control trial specifically designed to test the effect of the fibers from whole grains on type 2 diabetes development found that wholegrain fibers were not significantly better than the control arm at lowering glucose or improving insulin sensitivity. There was no difference between the groups in the incidence of type 2 diabetes.14 This study suggests that the addition of whole grains to a diet would not be sufficient to prevent type 2 diabetes.

Results from other experimental trials looking at blood sugar response to whole grains have been mixed. A 2017 systematic review of RCTs found that whole grains don’t raise blood sugar and insulin levels as much as refined grains do, at least in healthy people.15

However, an even more recent review of RCTs showed that individuals without diabetes had almost identical blood sugar responses after eating whole or refined wheat or rye. The blood sugar increase was much higher after eating white rice compared to whole-grain rice, though.16

At this time, there are only a few RCTs comparing blood sugar responses to whole vs. refined grains in obese people and those with diabetes. Overall, they have shown that replacing processed grains with whole grains improves blood sugar and insulin regulation.17

So is this a good strategy for diabetes reversal or even adequate glycemic control? That depends. If you are replacing highly refined grains, then whole grains are likely beneficial. But how does that compare to diabetes control without grains?

Multiple randomized trials show better glycemic control with carbohydrate restriction. This by definition means they excluded grains. Systematic reviews of the RCTs confirm these results. 18 And the American Diabetes Association (ADA) now endorses “Reducing overall carbohydrate intake for individuals with diabetes has demonstrated the most evidence for improving glycemia.”19

Whole grains can increase blood sugar more than commonly believed

Whole grains rank surprisingly high on the glycemic index (GI), the scale that measures how much a specific food raises blood sugar.20

The amount of processing grains undergo will influence their GI. Yet even minimally processed steel-cut oats have a moderate GI of 55, and quick-cooking oatmeal has a GI over 70.21 By contrast, cabbage and spinach have very low GIs of 15 and 6, respectively, and meat, fish, cheese, and fats are zero-GI foods.

As we already mentioned, whole grains have been shown to raise people’s blood sugar levels less than refined grains do in most experimental studies. But what is the blood sugar response to an entirely grain-free diet?

The paleo diet, which excludes grains, was found to be more effective than conventional dietary recommendations for lowering blood sugar and insulin levels in people at risk for metabolic syndrome, according to a 2015 meta-analysis of RCTs.22

Bottom line: Replacing refined grains with whole grains likely has significant benefits for blood sugar control. However, even whole grains raise blood glucose, so completely avoiding grains likely results in even better blood sugar control.

Wholegrain food still life

Whole grains and heart disease

Whole grains are often referred to as “heart-healthy” foods.

Indeed, many epidemiology studies show those who eat whole grains have lower risk of heart disease. However, as mentioned earlier, this does not prove that whole grains directly improve heart health, and given the inherent weakness of the data, it is just as likely due to healthy user bias (healthier people choose to eat whole grains and therefore have other healthy habits that contribute to a lower risk of heart disease).

On the other hand, higher-quality experimental studies frequently show improvements in certain heart disease risk factors when whole grains are substituted for refined grains. Two meta-analyses of RCTs found minor reductions in LDL cholesterol (0.09mmol/L) and triglycerides (0.04 mmol/L) in groups who consumed whole grains compared to groups who consumed refined grains, with oats appearing to have the most cholesterol-lowering power.23

However, reducing isolated risk factors does not necessarily translate into improved health, especially if one marker improves while others worsen (such as LDL improving but insulin resistance worsening.) That is why we need experimental studies looking at the end points that really matter- heart attacks, strokes and death- rather than less certain outcomes. To date, those studies are lacking.

Moreover, in 2017, the Cochrane Database performed a systematic review of nine RCTs and concluded there isn’t enough evidence to support claims that whole grains lower CVD risk. They made that conclusion due to the lack of high-quality controlled research, including small sample sizes and a high risk of bias (including funding from pro-cereal organizations) found in some of the trials they assessed.24

And a 2020 systematic review of 25 RCTs found that although studies show whole grains may reduce some heart disease risk factors, the data is low quality and likely not clinically relevant. In addition, there is insufficient evidence to recommend whole grains over refined grains for CVD prevention and treatment.25

This highlights the importance of understanding how low-quality research has influenced the support for the “heart-healthy” claim for whole grains. When scrutinized with a higher level of scientific integrity, the data doesn’t seem to hold up.

At this point in time, we can probably say that eating whole grains instead of refined grains is a good idea based on the other health evidence available but we should not have the expectation that we need whole grains in the diet to reduce our risk of CVD.

Whole grains and cancer risk

Cancer agencies and other groups often promote whole grains as a food that helps prevent cancer. This is based on mostly observational studies showing that people who eat the most whole grains are at lower risk for certain cancers, especially colorectal cancer. However, these studies are weakened by their low hazard ratios and by the fact that many other epidemiology studies fail to confirm those findings.26

A huge challenge in these studies is an accurate assessment of dietary intake. There are biomarkers for whole grain intake which have been studied but they have their own limitations too including a short half-life. This may be important when looking at bowel cancer prevention because a large amount of fibre might be needed, and this is hard to assess accurately currently.27

What’s more, experimental research (RCTs) testing the effect of consuming whole grains on cancer risk is entirely lacking. Remember, since observational studies show associations and not causation, they’re considered a very low quality of evidence. We don’t know if healthier people chose to eat more grains, or if eating the grains made them healthier, or if whole grains are simply a surrogate for food quality and fiber when compared to a diet full of refined and processed foods.

Bottom line: If whole grains replace refined grains and highly processed foods, then eating whole grains may be associated with reduced cancer incidence. However, based on the conflicting results of lower-quality observational trials and lack of RCT evidence, at this point there’s no convincing evidence that whole grains by themselves are protective against cancer.

Whole grains and other attributed health benefits

Whole grains have also been linked to a few other health improvements:

  • Reduced inflammation: Inflammation is believed to be at the root of many chronic diseases, including heart disease.28 Two meta-analyses of RCTs found that consuming whole grains instead of refined grains helped reduce the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6).29
  • Better gut health: Bacteria that reside in your colon produce short-chain fatty acids as a byproduct of digesting fiber. Results from RCTs suggest that consuming whole grains seems to boost production of these short-chain fatty acids, which nourish the gut and may improve insulin sensitivity.30

While these studies may sound convincing, keep in mind that they are not comparing whole grains to a grain-free, low-carb diet, but rather to the consumption of highly refined grains. It is possible the fiber content of the whole grains does play a role in these beneficial health effects – but you can get a wide range of different fibers within a low-carbohydrate diet including from nuts, seeds, avocados, low-carbohydrate fruits and non-starchy vegetables.

Dietary guidelines videos

Comparing whole grains to no-grains

To recap, the RCTs to date around whole grains demonstrate that, yes, eating a less-processed food is better than eating a highly-processed one.

What if studies compared consuming three servings of whole grains to three servings of non-starchy vegetables per day on a low-carb diet? It could be that under such an RCT whole grains might not show any benefit. But we don’t know that yet because such a trial has never been done, at least not one that we can find in the research literature.

One RCT, however, suggests that the no-grain approach might be superior. Although not a head-to-head trial pitting whole grains vs. no grains, back in 2007 researchers compared a grain-free, very-low-carb ketogenic diet to a low-glycemic-index (low-GI) diet, which included whole grains, in adults with type 2 diabetes.

At the end of the six-month trial, people in the grain-free keto group had significantly greater weight loss and reductions in blood sugar than the low-GI group.31

In order to strengthen the evidence, we need more RCTs comparing the health effects of low-carb grain-free diets to whole grain diets in both healthy people and those with diabetes.

Whole grains don’t provide unique nutritional benefits

While it’s true that whole grains contain vitamins, minerals, fiber, and polyphenols, these nutrients are found in many other foods, often in greater concentrations:

  • Fiber: Looking for fiber? Eat cruciferous vegetables, flaxseed, chia seeds, nuts, avocados, blackberries and raspberries — all of which provide more fiber than whole grains and far fewer digestible carbohydrates.
  • Magnesium: Although most whole grains are considered a good source of magnesium, mackerel, cooked greens, almonds, hemp seeds, pumpkin seeds and sunflower seeds contain equivalent or greater amounts per serving.
  • Thiamin: Seafood has the edge over whole grains for thiamin, and pork is higher in this B vitamin than any other food.
  • Niacin: Chicken, turkey, red meat (especially liver), fatty fish and avocado are better sources of niacin than whole grains.
  • Polyphenols: The jury is still out when it comes to the effects of plant phenols on health. However, you certainly don’t need to consume whole grains to get them. Vegetables, berries, olive oil, tea, spices, coffee, and dark chocolate contain an array of potentially beneficial polyphenols.32

Tolerance for whole grains varies among individuals

Some people can eat whole grains regularly without experiencing any issues. Others, however, cannot.

Individuals with celiac disease need to avoid gluten-containing whole grains. Gluten — a protein found in wheat, barley, rye and the wheat derivatives farro, spelt and triticale — can cause damage to the digestive tract and other symptoms when consumed in even small amounts by those with celiac disease.

People with celiac disease or non-celiac gluten sensitivity must eat a gluten-free diet in order not to experience symptoms.33 These individuals may be able to tolerate other types of whole grains like brown rice or quinoa. However, they might benefit from avoiding all grains, as even types that don’t naturally contain gluten are sometimes cross-contaminated with those that do during processing and packaging.34

There are also people for whom whole grains might cause other problems, such as IBS.35

Summary: should we eat whole grains or avoid them?

Whole grains have a clear edge over refined grains, with many studies showing they can be an integral part of a beneficial diet. However, there’s a lack of evidence comparing eating a diet high in whole grains to eating a grain-free diet.

This means that for people who tolerate grains and enjoy eating them, minimally processed and whole grain types are likely best. But if you don’t feel a need to eat grains, there is no nutritional need and likely no health need for them.

Keep in mind that whole grains don’t offer any unique nutritional benefits that can’t be found in other foods. Recommendations to consume them regularly to promote better health are not based on high-quality scientific evidence.

What’s more, given their high carbohydrate counts, they probably shouldn’t be consumed very often on a low-carb lifestyle, if at all. Fortunately, Diet Doctor has plenty of tasty grain-free low-carb bread and porridge recipes available that can be enjoyed instead.

Do you need whole grains? In all likelihood, no. At the end of the day, you can experience health benefits from eating a wide variety of keto-friendly whole foods that are delicious, satisfying, and often nutritionally superior to whole grains.

/ Franziska Spritzler, RD

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  1. Cochrane Database of Systematic Reviews 2017: Whole grain cereals for the primary or secondary prevention of cardiovascular disease [strong evidence]

  2. Proceedings of the National Academy of Sciences of America 2015: Multistep food plant processing at Grotta Paglicci (Southern Italy) around 32,600 cal B.P. [historical data; ungraded]

    Science 2009: Mozambican grass seed consumption during the Middle Stone Age [historical data; ungraded]

  3. Public Health Nutrition 2013: Identifying whole-grain foods: a comparison of different approaches for selecting more healthful whole grain products [overview article; ungraded]

  4. Whole Grains Council: Whole grains: an important source of essential nutrients [overview article; ungraded]

  5. Nutrients 2018: Whole grains and phenolic acids: a review on bioactivity, functionality, health benefits and bioavailability [overview article; ungraded]

  6. The Lancet 2019: Carbohydrate quality and human health: a series of systematic reviews and meta-analyses [Mixed observational and randomized clinical trial data; very weak evidence for significant health benefits]

  7. As an example, a large nutritional epidemiology study, the PURE study, reported that the intake of whole grains had no association with cardiovascular risk, either positive or negative. Refined grains, on the other hand, had an association with increased cardiac risk. Keep in mind this represents the very weak nutritional epidemiology on which much of the whole grain literature is based.

    BMJ 2021: Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study [nutritional epidemiology study with HR<2; very weak evidence]

  8. Journal of Nutrition 2008: ocial desirability trait influences on self-reported dietary measures among diverse participants in a multicenter multiple risk factor trial [observatkional study, weak evidence]

  9. This quote is taken from the ChooseMyPlate website

  10. American Journal of Clinical Nutrition 2013: Whole grain and body weight changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies [strong evidence]

  11. Advances in Nutrition 2019: Whole-grain consumption does not affect obesity measures: An updated systematic review and meta-analysis of randomized clinical trials [strong evidence]

  12. Resting metabolic rate

    American Journal of Clinical Nutrition 2017: Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women [moderate evidence]

    Belly fat

    Plant Foods for Human Nutrition 2018: Effects of whole grain wheat bread on visceral fat obesity in Japanese subjects: a randomized double-blind study [moderate evidence]

    Insulin resistance

    Metabolism 2018: A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial [moderate evidence]

    Inflammation and body weight

    Gut-British Medical Journal 2019: Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial [moderate evidence]

  13. European Journal of Clinical Nutrition 2017: Wholegrain rye, but not wholegrain wheat, lowers body weight and fat mass compared with refined wheat: a 6-week randomized study [moderate evidence]

  14. Diabetologia 2018: Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT) [randomized trial; moderate evidence]

  15. Nutrients 2017: Whole grain intake and glycaemic control in healthy subjects: a systematic review and meta-analysis of randomized controlled trials [strong evidence]

  16. American Journal of Clinical Nutrition 2018: The effects of whole-grain compared with refined wheat, rice, and rye on the postprandial blood glucose response: a systematic review and meta-analysis of randomized controlled trials [strong evidence]

  17. Nutrients 2016: Short- and long-term effects of wholegrain oat intake on weight management and glucolipid metabolism in overweight type-2 diabetics: a randomized control trial [moderate evidence]

    Metabolism 2018: A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial [moderate evidence]

    American Journal of Clinical Nutrition 2014: Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: a randomized controlled-feeding trial [moderate evidence]

  18. The advantage of a low-carb diet in type 2 diabetes has been recognized in several systematic reviews and meta-analyses or RCTs. Here are two recent examples:

    Diabetes Research and Clinical Practice 2018: Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis [strong evidence]

    BMJ Open Diabetes Research and Care 2017: Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes [strong evidence]

    Here are five RCTs demonstrating the benefits of low-carbohydrate diets in people with type 2 diabetes:

    Nutrients 2018: The effect of low-carbohydrate diet on glycemic control in patients with type 2 diabetes [moderate evidence]

    Nutrition & Diabetes 2017: Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes [moderate evidence]

    Diabetes Care 2014: A very low-carbohydrate, low–saturated fat diet for type 2 diabetes management: a randomized trial [moderate evidence]

    Nutrition & Metabolism 2008: The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus [moderate evidence]

    Diabetic Medicine 2004: Short-term effects of severe dietary carbohydrate-restriction advice in type 2 diabetes–a randomized controlled trial [moderate evidence]

    However, it’s worth noting that many of these studies and meta-analyses are not straightforward to interpret. One of the reasons is that in general low-carbohydrate diets result in more weight loss in these types of trials and this is a confounding factor because weight loss also lowers glucose. The second is that in most cases we don’t know what people ate during the study. As we illustrate in our protein guide, the higher protein content of many low-carbohydrate diets might be an important part of the glucose lowering effects. So maybe it’s not just the carbohydrate reduction – it might be the protein increase, too. Finally, in quite a few of these studies, the low-carbohydrate group often had reductions in their medications compared to the higher carbohydrate group. This might have reduced the difference in glucose levels between the low and high carbohydrate groups. Nevertheless, at this point in time, the weight of the evidence points towards lower carbohydrate diets as being more beneficial at managing type 2 diabetes than higher carbohydrate diets.

  19. Diabetes Care: Nutrition therapy for adults with diabetes or prediabetes: A consensus report [consensus report; ungraded]

  20. American Journal of Clinical Nutrition 2009: Glycemic index, postprandial glycemia, and the shape of the curve in healthy subjects: analysis of a database of more than 1000 foods [non-randomized trial; weak evidence]

  21. British Journal of Nutrition 2015: Systematic review of the effect of processing of whole-grain oat cereals on glycaemic response [systematic review of uncontrolled studies; weak evidence]

  22. American Journal of Clinical Nutrition 2015: Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis [strong evidence]

  23. American Journal of Clinical Nutrition 2015: Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies [strong evidence]

    European Journal of Nutrition 2018: Comparative effects of different whole grains and brans on blood lipid: a network meta-analysis [strong evidence]

  24. Cochrane Database of Systematic Reviews 2017: Whole grain cereals for the primary or secondary prevention of cardiovascular disease [strong evidence]

  25. Journal of the Academy of Nutrition and Dietetics 2020: The effect of replacing refined grains with whole grains on cardiovascular risk factors: a systematic teview and meta-analysis of randomized controlled trials with GRADE clinical recommendation [strong evidence]

  26. Nutrition Reviews 2016 : Consumption of whole grains and cereal fiber in relation to cancer risk: a systematic review of longitudinal studies [very weak evidence]

  27. American Journal Of Clinical Nutrition 2009: Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake [nonrandomized study, weak evidence]

  28. European Cardiology Review 2017: Inflammation revisited: atherosclerosis in the post-CANTOS era [overview article; ungraded]

  29. Medicine (Baltimore) 2018: Whole grain diet reduces systemic inflammation [systematic review of randomized controlled trials; strong evidence]

    Journal of the American College of Nutrition 2018: Effects of whole-grain consumption on selected biomarkers of systematic inflammation: a systematic review and meta-analysis of randomized controlled trials [strong evidence]

  30. American Journal of Clinical Nutrition 2017: Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults [moderate evidence]

    Nutrition 2016: Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome [randomized trial; moderate evidence]

    British Journal of Nutrition 2015: Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects [moderate evidence]

  31. Nutrition & Metabolism 2008: The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus [randomized trial; moderate evidence]

    However, since the weight loss difference was so large – the grain-free group lost 11.1 kg versus 6.9 kg in the low-GI group, this may be enough to explain the difference in glucose concentrations by weight loss alone.

  32. Frontiers in Nutrition 2018: The role of polyphenols in human health and food systems: a mini-review [overview article; ungraded]

  33. Journal of the American Medical Association 2017: Celiac disease and nonceliac gluten sensitivity: a review [overview article; ungraded]

  34. Nutrition Research 2018: Oat safety for celiac disease patients: theoretical analysis correlates adverse symptoms in clinical studies to contaminated study oats [review of clinical studies; moderate evidence]

  35. Gastroenterology 2014: A diet low in FODMAPs reduces symptoms of irritable bowel syndrome [randomized trial; moderate evidence]