Intermittent fasting side effects

Are you interested in trying intermittent fasting? You aren’t alone. Intermittent fasting has quickly become one of the most popular and effective ways to achieve weight loss and improve health conditions such as type 2 diabetes, high blood pressure, and metabolic syndrome.1

As with many lifestyle interventions, some people may experience unwanted side effects when fasting. This guide will explain what you may encounter and how to prevent any undesirable effects.

We’ll also cover who may not be the right candidate for fasting. Make sure you continue reading to determine into which category you fall.

What is intermittent fasting?

Intermittent fasting is a general term that encompasses time-restricted eating (fasting less than 24 hours), short-term fasting (fasting less than 36 hours), and long-term fasting (fasting more than 36 hours).2

You can learn more about intermittent fasting in our main guide to intermittent fasting.

Potential fasting side effects and tips for preventing them

Most people tolerate intermittent fasting without any serious trouble. However, mild side effects are common, especially when starting.34 A general rule for fasting is that mild symptoms are expected, but severe or disabling symptoms are not typical and indicate you should immediately break your fast. Fortunately, these are very rare.

It is also essential to plan ahead and anticipate how you will respond if you do experience side effects while fasting. Knowledge is power! Be prepared so that you can increase your chances of success.


Hunger is likely the most common side effect of fasting.5 The key is to recognize that most hunger is benign and can be ignored.6

Many find that hunger comes and goes in waves; simply ignoring it will help it disappear.7 Others find distractions helpful. Going for a walk, engaging in conversation, or engaging your brain in a challenge ( e.g. a work project, a puzzle, or a game) are all activities that can help. Others find that sparkling water, hot water with lemon, or water with salt can also reduce hunger feelings.

The most important thing is to anticipate that you might feel hungry and realize this is okay. Plan ahead how you will respond to this sometimes nagging feeling, so you aren’t caught off guard.


Some people find they become a bit weak while fasting. It may require decreasing the intensity and/or duration of exercise, but time-restricted eating should not prevent you from exercising at all.8

Those with physically demanding jobs, however, may find this to be an issue. Staying well-hydrated and supplementing with salt are two potential ways to prevent feelings of weakness.9

While mild weakness is normal, you should not feel extreme weakness or difficulty walking or standing. If that is the case, you should break your fast and contact your healthcare professional.

Headache and dizziness

As with weakness, mild headaches or dizziness are relatively common and may be prevented with hydration and salt intake.10

However, severe, debilitating headaches or severe dizziness are not typical and indicate it is time to break the fast.


Some may feel less mentally sharp while fasting, but this practice should not lead to outright confusion. If that is the case, break the fast and consult your healthcare professional. Conversely, many people feel mentally sharper as they go deeper into ketosis with fasting. It may be worth experimenting to see how you respond.


It makes sense that if you are eating less, you will naturally have fewer bowel movements. Going to the bathroom less frequently is a normal consequence of fasting, and does not mean you are constipated.

If you do not feel bloated or uncomfortable and you don’t have to strain to have a bowel movement, then you likely are not constipated. However, if you experience these symptoms, you may want to increase your hydration or try magnesium supplements.11


For some, fasting can relieve heartburn symptoms. For others, it can worsen symptoms. Again, experimenting with fasting will help you determine how you respond.

Elevated blood sugar

While fasting may benefit overall blood sugar control, some find their morning blood sugar rises.

This is called the “dawn phenomenon.” It occurs when the liver releases glucose into the bloodstream in response to receiving signals that the body may need more energy after a long rest.12

Those who follow a low-carb diet and experience elevated blood sugar with fasting usually find their highest levels are upon waking (almost always less than 120mg/dl), and the rest of the day, they have normal, flat blood sugar levels.13

As we discuss in our guide on the dawn effect, these mildly elevated fasting blood sugar levels may not be of clinical concern, especially if they are only present while fasting. However, if someone’s fasting blood sugar increases regularly above 130, they may want to consult their physician.

Low blood sugar

Low blood sugar in the absence of glucose-lowering medications is rare.14

If someone feels sweaty, extremely weak, nauseous, or overly lightheaded, it is possible – but not likely – they are suffering from hypoglycemia. In this situation, it’s helpful to check a blood sugar reading— if it can be done safely. Otherwise, you should break your fast right away and consult your healthcare provider.15

Refeeding syndrome

This is an extremely rare but very serious condition that can occur after prolonged fasting in those who are underweight or malnourished.16 These people can experience potentially fatal shifts in fluids and electrolytes during refeeding.

Most practitioners of intermittent fasting will never have to worry about this, and it is one reason why fasting is contraindicated for underweight or malnourished individuals.


Who should not fast?17

The following categories of people should not practice intermittent fasting.

  1. Anyone who is underweight or malnourished: Fasting could deprive underweight or malnourished individuals of the nutrition and energy they need.
  2. Anyone with a history of eating disorders (such as anorexia or bulimia): Fasting may trigger a relapse of these disordered eating behaviors.
  3. Children and adolescents: Children and adolescents have greater growth demands and therefore need a steady supply of nutrition and energy. We recommend overweight or obese children and adolescents focus on healthier eating patterns without fasting.
  4. Women who are pregnant or breastfeeding: Pregnancy and breastfeeding increase the mother’s metabolic and nutrient needs, and fasting can result in a failure to meet those needs.
  5. Women who are trying to conceive: Fasting can trigger a woman’s body to ovulate irregularly or completely stop ovulating, thereby decreasing the chance of pregnancy.
  6. Those who find fasting triggers cravings and overconsumption: Some people don’t have any contraindications to fasting, but they find fasting makes them much more likely to binge eat, choose higher-carb foods, or eat more calories than they normally would. This counteracts the benefits of fasting and therefore they should avoid fasting.

Who needs special guidance?18

Individuals in the following categories may be able to successfully fast, but they should seek care from an experienced healthcare clinician to ensure safety. If you need help finding someone with knowledge in this area, please see our clinicians map.

  1. Those who take diabetes medication: Someone with either type 1 or type 2 diabetes who takes medications that lower blood sugar — such as insulin, sulfonylureas, and others — may be at risk of dangerously low blood sugars when fasting. This applies equally to long- and short-term fasts.

    These individuals may still be able to fast, but they will need careful coaching and monitoring from an experienced professional. You can see our informational resource meant to educate clinicians and help them guide their clients to safely start and maintain a fasting routine.
  2. Those who take blood pressure medications: While the effect of fasting on blood pressure is much less dramatic than the effect on blood sugar, some may find their blood pressure drops too low when fasting. This is more relevant for longer-term fasts, but can also be an issue with short-term fasts. Close supervision with a physician is recommended.19
  3. Those who take other medications: Some medications — such as aspirin, ibuprofen, other NSAIDs, metformin, beta blockers, and others — may cause digestive upset when taken on an empty stomach.

    If you are considering fasting, that does not mean you should simply skip these medications. It is important to first have a discussion with your physician regarding your options when it comes to taking your medications regularly, skipping them, or changing their timing.
  4. Those with serious medical conditions: Any serious liver, kidney, heart, or other condition may negatively impact one’s ability to fast safely. Anyone with these conditions should get clearance from their physician first.

How to break a fast

How you break a fast can be just as important as the fast itself.

For time-restricted eating (fasts less than 24 hours) and short-term fasts (less than 36 hours), there are only a few things to consider:

  1. Make sure you have control over what you will eat when you break your fast. The last thing you want is to be hungry and looking for nutritious food, only to find yourself at a work event with pizza, bagels, and doughnuts.
  2. Don’t “make up for lost calories.” Remember, part of the benefit of time-restricted eating is a natural reduction in calories. Eat your normal meals as if you hadn’t fasted.
  3. The only exception to rule #2 is that you may need to add a little extra protein to your meals to ensure you reach your daily targets. This is especially important for those eating one meal a day (OMAD). Learn more about protein needs in our guide: “How much protein should I eat?”


Keto OMAD meal-plan
Keto meal plan: A week of OMAD #1

OMAD is short for One Meal a Day. It’s a hot new way to do intermittent fasting and our new meal plan makes it super easy to do. The meal plan has you alternating between OMAD one day and two meals the next.


For longer-term fasts (greater than 36 hours), you may need to take extra precautions to avoid side effects such as bloating, heartburn, or diarrhea. The following suggestions can help minimize these risks:

  1. With longer fasts, it is even more important to make sure you have complete control over when and what you will eat to break the fast. Don’t get caught off guard!
  2. Start with a snack, not with a full meal. You can start with bone broth, low-carb soup, or a small snack. You don’t want to eat anything too heavy for your first food intake.
  3. Two or three hours after your snack, you can have your first meal. Again, keep it relatively simple. Avoid heavy or complex sauces. Go for a small amount (no bigger than the palm of your hand) of simply prepared protein, low-carb veggies cooked in butter, or EVOO and a quarter avocado.

With longer fasts, it’s important to remember to have a transition day. For example, a five-day fast is a six-day protocol including five days of fasting and one transition day. You can then resume regular eating on the seventh day. For more information, see our guide on breaking a fast.

Key takeaways

Intermittent fasting can be a helpful addition to any healthy lifestyle, and most people can safely and effectively incorporate fasting into their lives. Make sure you are aware of potential side effects before you start fasting and anticipate your response. That way you won’t get caught off guard and you will be prepared to succeed.

/ Dr. Bret Scher, MD



Intermittent fasting side effects - the evidence

This guide is written by Dr. Bret Scher, MD and was last updated on June 17, 2022. It was medically reviewed by Dr. Michael Tamber, MD on November 10, 2020.

The guide contains scientific references. You can find these in the notes throughout the text, and click the links to read the peer-reviewed scientific papers. When appropriate we include a grading of the strength of the evidence, with a link to our policy on this. Our evidence-based guides are updated at least once per year to reflect and reference the latest science on the topic.

All our evidence-based health guides are written or reviewed by medical doctors who are experts on the topic. To stay unbiased we show no ads, sell no physical products, and take no money from the industry. We're fully funded by the people, via an optional membership. Most information at Diet Doctor is free forever.

Read more about our policies and work with evidence-based guides, nutritional controversies, our editorial team, and our medical review board.

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  1. International Journal of Obesity 2011: The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomised trial in young overweight women [moderate evidence]

    The following study was a systematic review of 4 RCTs selected using the GRADE system to pick the highest-quality evidence available.

    Cureus 2018: Intermittent fasting: the choice for a healthier lifestyle [systematic review of randomized trials; strong evidence]

    The following studies showed improved blood sugar and insulin levels

    Nutrition Reviews 2014: Time-restricted feeding and risk of metabolic disease: a review of human and animal studies [moderate evidence]

    The British Journal of Nutrition 2008: Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults [weak evidence]

    PloS One 2012: Effects of meal frequency on metabolic profiles and substrate partitioning in lean healthy males [weak evidence]

    JAMA Network Open 2018: Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with type 2 diabetes: a randomized noninferiority trial [moderate evidence]

    Diabetes Research and Clinical Practice 2016: The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial [moderate evidence]

  2. These are the definitions we use at Diet Doctor. There are not currently universally accepted definitions, so you are likely to encounter others. We feel this best represents the literature and the practical implementation of fasting

  3. The list of symptoms comes from multiple intervention trials as well as clinical experience. The possible symptoms are summarized in this overview article that examined people fasting for two or more consecutive days, though it is possible that the frequency and severity of side effects may be less in people fasting for shorter durations.

    BMC Complementary and Alternative Medicine 2018: Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting [overview article]

  4. The following meta-analysis of multiple trials concluded “No serious adverse events were reported across studies. Three studies reported minor physical and psychological effects.”

    JBI Database of Systematic Reviews and Implementation Reports 2018: Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis [strong evidence]

  5. This is based on clinical experience of low-carb practitioners and was unanimously agreed upon by our low-carb expert panel. You can learn more about our panel here [weak evidence].

  6. In fact, research suggests that eating within a small window and fasting for 16-18 hours may decrease appetite in some people:

    Obesity 2019: Early time‐restricted feeding reduces appetite and increases fat oxidation but does not affect energy expenditure in humans
    [randomized crossover trial; moderate evidence]

    Cell Metabolism 2019: Early time‐restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes [randomized crossover trial; moderate evidence]

  7. This is based on clinical experience of low-carb practitioners and was unanimously agreed upon by our low-carb expert panel. You can learn more about our panel here [weak evidence].

  8. The following study shows the safety and efficacy of exercising in a fasted state.

    Scandinavian Journal of Medicine & Science in Sports 2018: Effects of fasted vs fed-state exercise on performance and post-exercise metabolism: A systematic review and meta-analysis [meta-analysis of
    randomized and non-randomized studies; moderate evidence]

  9. This is based on clinical experience of low-carb practitioners and was unanimously agreed upon by our low-carb expert panel. You can learn more about our panel here [weak evidence].

  10. This is based on clinical experience of low-carb practitioners and was unanimously agreed upon by our low-carb expert panel. You can learn more about our panel here [weak evidence].

  11. Clinical experience suggests that magnesium citrate or oxide may have a greater intestinal stimulating effect that others,

  12. Endocrine Practice 2005: The dawn phenomenon revisited: implications for diabetes therapy [overview article]

  13. This is based on clinical experience of low-carb practitioners and was unanimously agreed upon by our low-carb expert panel. You can learn more about our panel here [weak evidence].

  14. The following study in hospitalized patients found 36 out of 10,000 patients experienced hypoglycemia. It is likely to be much lower in a healthier, non-hospitalized population.

    PLoS One 2012: Hypoglycemia in non-diabetic in-patients: clinical or criminal?
    [nonrandomized study, weak evidence]

  15. Please note that without an accurate blood sugar reading during the symptoms, it is extremely difficult to make a diagnosis of hypoglycemia.

  16. Most of the evidence on refeeding syndrome is from studies in critically-ill hospitalized patients or observations from underweight or malnourished individuals. That makes it challenging to know how this applies to overweight or otherwise healthy individuals undergoing a voluntary fast.

    BMJ 2008: Refeeding syndrome: what it is, and how to prevent and treat it [overview article; ungraded]

  17. This list is derived from clinical experience and the compilation of data from multiple sources – but it is based mostly on expert consensus. There have not been – and likely will not be – any controlled trials demonstrating danger in certain high-risk groups.

  18. This list is derived from clinical experience and the compilation of data from multiple sources – but it is based mostly on expert consensus. There have not been – and likely will not be – any controlled trials demonstrating danger in certain high-risk groups.

  19. Interestingly, some individuals notice a blood pressure increase during fasting, as mentioned in the following paper. However, the greater short-term clinical risk is likely from a significant decrease, rather than an increase, in blood pressure.

    BMC Complementary and Alternative Medicine 2018: Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting [overview article]