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Insulin and Fatty Liver Disease

Dr. Alfred Frohlich from the University of Vienna first began to unravel the neuro-hormonal basis of obesity in 1890. He described a young boy with the sudden onset of obesity who was eventually diagnosed with a lesion in the hypothalamus area of the brain. It would be later confirmed that hypothalamic damage resulted in intractable weight gain in humans, establishing this region as a key regulator of energy balance.

In rats and other animals, hypothalamic injury could experimentally produce insatiable appetites and induce obesity. But, researchers quickly noticed something else, too. All these obese animals shared characteristic liver damage, which was occasionally severe enough progress to complete destruction. Looking back at hereditarily obese strains of mice, they noted the same liver changes. Strange, they thought. What does the liver have to do with obesity? Continue Reading →

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Why High Insulin Precedes Type 2 Diabetes

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Joseph Kraft is a medical doctor who measured over 14,000 oral glucose tolerance tests in his lifetime. This is a standard test to measure the blood glucose response to a standardized amount of glucose over 2 hours. The difference is that he measured over 5 hours and included blood insulin levels. A summary of his work is here and Prof Grant also reviews it nicely here. Ivor Cummins, The Fat Emperor, has also reviewed it nicely here.

kraft-curves-cummins-1024x658What Dr. Kraft had discovered is that you can make the diagnosis of type 2 diabetes much earlier than the standard OGTT by measuring insulin. The OGTT itself is meant diagnose T2D earlier than blood glucose by measuring the glucose response to a 75g load of glucose.

But people with normal OGTT may still have an abnormal insulin response. Those people who respond with excessive secretion of insulin to 75g of glucose are at very high risk of eventually developing T2D as well. So the insulin response is even earlier, which means you can diagnose ‘diabetes in situ’, which means incipient diabetes. Continue Reading →

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How to Control Your Insulin Efficiently


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By controlling the insulin in your body you can control both your weight and many other aspects of your health.

But exactly what does insulin do in your body? What factors raise and lower insulin? How can you control your insulin efficiently?

Dr. Ted Naiman gives you tons of knowledge in this great presentation from the Low-Carb Cruise 2016. It’s full of ideas that you can put to use right away.

Watch a new highlight from the presentation above (transcript). The full 45-minute presentation is available (with captions and transcript) with a free trial or membership:

Hyperinsulinemia – What Insulin Does In Your Body – Dr. Ted Naiman

Start your free membership trial to get instant access to this and over 190 other video courses, movies, interviews, or presentations. Plus Q&A with experts, etc.

Continue Reading →

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A New Paradigm of Insulin Resistance

Man with big belly

What exactly is insulin resistance? One of insulin’s jobs is to help move glucose from the blood into the cells for energy. When blood glucose remains elevated despite normal or high levels of insulin, this is called insulin resistance. The cells are resisting insulin’s pleas to take up glucose. But why is this happening? What causes insulin resistance? Continue Reading →

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Insulin Causes Insulin Resistance

Insulin

Laura was only 25 when she was diagnosed with an insulinoma, a rare tumor that secretes abnormally large amounts of insulin in the absence of any other significant disease. This forces blood glucose very low causing recurrent episodes of hypoglycemia.

Laura was constantly hungry and soon began to gain weight. As insulin is a major driver of obesity, weight gain is a consistent symptom of the disease. She noticed problems with concentration and coordination, as she had inadequate glucose to maintain brain function. One night, as she was driving, she lost control of her feet and narrowly avoided an accident. Continue Reading →

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Searching for the X Factor

Young Boy Looking Through Binoculars Hiding in Grass

Hyperinsulinemia plays the dominant role in provoking obesity and fatty liver disease, but what causes it?

Insulin is intimately related to our diet, so that was naturally the first place to look. Highly refined and processed carbohydrates, such as sugars, flour, bread, pasta, muffins, donuts, rice and potatoes are well known to raise blood glucose and insulin production. This became known as the carbohydrate-insulin hypothesis, and forms the rational basis for many of the low-carbohydrate diets such as the Atkins diet.

These are not new ideas, but very old ones. Continue Reading →

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Is It Insulin or Calories that Make Us Gain Weight?


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What really matters for weight loss? Calories in and calories out, or are our bodies’ weight carefully regulated by hormones, such as the fat-storing hormone insulin?

In this presentation from the 2015 LCHF Conference in Cape Town I describe why the second explanation – about hormones – makes much more sense. And why the first one – about calories – is a simplistic description that completely fails to address the cause of obesity.

Watch it

Watch a new 2-minute highlight above (transcript). The full 36-minute presentation is available (with captions and transcript) with a free trial or membership:

Weight Control: The Calories vs Insulin Theory – Dr. Andreas Eenfeldt

Start your free membership trial to get instant access to over 175 other video courses, movies, interviews, or other presentations. Plus Q&A with experts, etc.

Continue Reading →

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Fiona Godlee: Pushing Diabetic Patients to Take Insulin Is a “Medical Scam”

Fiona Godlee

Fiona Godlee

Pushing people with type 2 diabetes to take insulin, rather than tackling the underlying lifestyle factors is a medical scam, according to BMJ editor in chief Fiona Godlee:

To put patients on insulin is a big push by industry and the doctors who in turn are influenced by the industry.

The Economic Times: Pushing Diabetics to Take Insulin Is a Medical Scam: Fiona Godlee

Continue Reading →

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Obesity – Solving the Two-Compartment Problem

Calories in, calories out – it's not that simple

One of the major mistakes made by the Calories In/ Calories Out (CICO) hypothesis is the presumption that energy is stored in the body as a single compartment. They consider that all foods can be reduced to their caloric equivalent and then stored in a single compartment in the body (Calories In). The body then uses this energy for basal metabolism and exercise (Calories Out).

This model looks something like this:

1compartmentmodelAll energy is stored in that one compartment. However, this model is a known to be a complete fabrication. It does not exist except in the fevered imaginations of CICO zealots. Food energy is not stored in a single compartment, but two compartments (glycogen and body fat).

According to this incorrect model, simply reducing calories going in, or increasing the amount going out, reduces the amount of body energy stored as fat. Of course, this Eat Less, Move More (or Caloric Reduction as Primary) strategy has a known success rate of about 1% or a failure rate of roughly 99%. After all, we’ve all tried it. It just doesn’t work. Study after study proves the futility of this advice, based on a flawed understanding of physiology. This does not deter any of the medical or nutritional authorities to question the sagacity of their advice, though.

To better understand how energy is stored in the body, it is more accurate to use a two-compartment model. Continue Reading →

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Is Salt the Cause of Hypertension?

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Salt intake is often considered one of the main factors behind high blood pressure. But the evidence supporting this idea is very weak, and eating less salt has a very marginal effect (and could sometimes even be dangerous).

Likely, there are other factors, like high levels of insulin, that play a much more powerful role in raising blood pressure. Professor Grant Schofield has written a very interesting piece on this, and even had a letter published in the Lancet:

High insulin causes salt retention, that can result in high blood pressure. If you suffer from this, it might be a good idea to switch to a low-carb diet, that lowers the insulin. That means that you’re treating the cause, not just a symptom.

How to Normalize Your Blood Pressure

Continue Reading →

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