Starting a keto diet with diabetes medications

Testing blood sugar

So you have diabetes and you want to try a keto diet? Congratulations! It may be the single best thing you could ever do for your health. It can start to reverse your type 2 diabetes, and dramatically increase your blood sugar control with type 1 diabetes.

However, you need to know what you are doing. Once you start eating low carb you may instantly have to lower any insulin doses, a lot.

Avoiding the carbohydrates that raise your blood sugar decreases your need for medication to lower it. Taking the same dose of insulin as you did prior to adopting a keto diet might result in hypoglycemia (low blood sugar).

You need to test your blood sugar frequently when starting this diet and adapt (lower) your medication. This should ideally be done with the assistance of a knowledgeable physician.

No drugs

If you have diabetes and you’re treated either by diet alone or just with Metformin there is no risk of low blood sugar on a keto diet. You can get started right away.


As a general guide you may need to lower your doses by 30-50% or more when starting a strict low-carb diet.


Unfortunately there’s no way to know the doses required in advance. You’ll have to test your blood sugar frequently and adapt (lower) insulin doses. This should ideally be done with the assistance of a knowledgeable physician.

Note that as a general rule it’s easier to err on the low side, and take more insulin later if needed. That’s fine. If instead you overdose and get low sugar you’ll have to quickly eat or drink more carbohydrates, and that obviously reduces the effect of the low-carb diet.

Insulin in type 1 diabetes

The advice on insulin above generally applies to type 1 diabetes too. A low-carb, high-fat diet can be fantastic for empowering people with type 1 diabetes to get steady blood sugars. It results in much fewer and milder highs or hypos (when insulin doses are adapted).

If you get regular hypos you should consider lowering your insulin.

One word of warning though: A strict low carb diet results in ketosis, a normal physiological state. This is why it’s called a keto diet. A keto diet that also restricts protein to moderate amounts can result in quite high, but still physiological, ketone levels (around 1 – 3 mmol/L, sometimes more).

This is fine for healthy people, but in type 1 diabetes this means you’re uncomfortably close to ketoacidosis (usually at least 10-15 mmol/L). All that’s needed then is forgetting a couple of insulin shots, or an insulin pump malfunction, and you might end up very sick in the hospital.

Thus it may be best in type 1 diabetes to try a more moderate low-carb diet, perhaps with around 50 grams of carbs a day, so that you stay out of deeper ketosis (>1.5 mmol/L).

Do not do a strict low-carb diet (below 20 grams a day) unless you’re certain of how to handle this risk. Adding for example a fruit or two a day to it is probably wise, if you have type 1 diabetes. Just to be safe.

With that said, a low-carb diet can have fantastic results for people with type 1 diabetes:


Insulin-releasing pills


Some pills for type 2 diabetes work by releasing more insulin in the pancreas. These can also result in low blood sugar on a keto diet, even if the risk is slightly smaller than with injected insulin.

These pills are called sulfonylureas and include Minidiab, Euglucon, Daonil, and Glibenclamide.

You may need to reduce the dose or stop these drugs on a low-carb diet, as you may rapidly become too healthy for them. Discuss it with your doctor in advance.


Metformin tablets can be safely taken on a keto diet. There’s no risk of low blood sugar if you’re only on Metformin.

GLP-1 agonists (e.g. Victoza) and DPP-4 inhibitors (e.g. Januvia)

These drugs should rarely lead to low blood sugar on a keto diet by themselves. But be observant, check your blood sugar often and discuss it with your doctor as needed.


SGLT2 inhibitors (e.g. Farxiga, Jardiance, Invokana)

These drugs1 are a good way to treat type 2 diabetes, but as a known side effect they increase the risk of a dangerous condition called ketoacidosis. It’s likely that this side effect could become more common on a strict low-carb diet. Proceed with caution and discuss it with your doctor.

If you get symptoms of ketoacidosis: extreme thirst, nausea, vomiting, confusion etc. you should stop the medication, eat carbs and contact a doctor immediately.



Top diabetes videos


Return to the keto beginner’s guide

A keto diet for beginners

Low carb for doctors

Are you a doctor or do you know one? Here’s our low carb for doctors resource, with information on how to safely handle medications on a low-carb diet:

Low carb for doctors

  1. For more brand names and information check out the Wikipedia page about this class of drugs.