Biased paper suggests ketones are as harmful as glucose

A new hypothesis article published in Nutrition is stirring controversy on Twitter. The paper postulates that ketones from a ketogenic diet produce the same vascular damage that elevated glucose does. This is a concerning point if it is true.
But the most important thing to understand is that this paper doesn’t have a single piece of credible evidence to support this idea. It is a “hypothesis article,” or essentially a thought experiment. That’s all it is.
One individual with a grasp of complex scientific and chemical processes is speculating that ketones could cause damage, but he is not presenting any actual evidence to suggest it is the case.
In fact, the data the author did present causes him to lose credibility in my mind. He starts off the paper stating, “Low-carbohydrate, ketogenic diets are associated with increased mortality.” This is simply not true.
Some very weak observational studies (using food frequency questionnaires, shrouded with confounding variables and healthy user bias, and defining “low-carb” as 40% calories from carbs) show a weak increased risk of mortality. But this has nothing to do with a ketogenic diet, which usually sources only 5% of energy from carbs.
He also quotes a food-frequency-questionaire-based study from Sweden, where authors assessed dietary patterns at enrollment and had no other assessment of what subjects ate for the duration of the 16-year study.
In that study, the “low-carb” cohort ate 123 grams of carbs per day. The authors concluded there was minimal increased risk of cardiovascular disease (1.04) with lower carb and higher protein consumption. Again, this has nothing to do with ketosis or a true low-carb diet (or credible science for that matter).
When a scientist tries to equate these studies with a ketogenic diet, it either demonstrates their misunderstanding of science, or it shows their personal agenda to “attack” a ketogenic diet by any means necessary.
The author goes even further to degrade his credibility. He uses the medical emergency of ketoacidosis as an example of how “ketosis is not without risks.”
Again, the author seems to not understand or to purposely conflate the body’s process of producing low levels of ketones due to avoiding carbs — a natural process that has occurred across evolution — with the extreme levels of ketones found in ketoacidosis that are almost impossible to obtain without a disease process such as type 1 diabetes. This is a misleading example that has nothing to do with the safety of nutritional ketosis.
Putting his inaccurate evaluation of nutritional science aside, the author’s whole premise is that “ketones are reactive towards proteins through the same mechanisms as glucose.” He discusses a potential chemical pathway where this could be the case, but he offers no evidence showing that it actually is the case.
Interestingly, the author would have benefitted his argument of he hadn’t “shown his hand” with his biased and inaccurate interpretation of the science of ketosis. So, how should we interpret this paper?
This idea could be an interesting hypothesis around which a lab might start designing experiments. But that is about all we can conclude. Until there is credible evidence that the hypothesis has clinical merit, we have to interpret this as someone with an agenda putting forth an idea without credible evidence.
Thanks for reading,
Bret Scher, MD FACC
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My grandfather was a doctor in San Francisco who lost his life to the Spanish Flu. Be careful in your practice.
This can only happen in a type 1 diabetic.
Keto/Low carb works by lowering blood sugar. Many people with type 1 diabetes are able to better control their blood sugars by keeping their carb intake low. Yes, it requires more careful and consistent monitoring but it is definitely possible!
https://www.dietdoctor.com/diabetes/type-1
While rare, there are other times a person is at risk of ketoacidosis; specifically certain classes of medications for people with type 2 diabetes.
https://www.dietdoctor.com/low-carb/with-diabetes-medications#sglt2
You are free to disagree, by all means.
(Although the data on this very website prove exactly the point that Type-1-Diabetics are well advised to go very low carb.)
Science is not about ‘alternative facts’; if you have no data, you make an assumption, but then you should call it that. Which is what Dr Scher tries to explain here. He’s even encouraging further studies (or in this case any single one to literally begin with) to be performed.
I do hope you will be able to control your blood sugars and find optimal health. A good read might be Dr Bernstein’s books on this topic, even specifically for Type 1.
Here are some interesting quotes:
He explains why he explains diabetes in depth, when only a minority of the population is diabetic.
“Quite simply, the reason is that a diet rich in complex carbohydrates but low in simple sugars, which is recommended for those with diabetes, should form the basis of a healthy diet for everyone. (...) This is why eating porridge for breakfast keeps you going until lunchtime: a steady stream of glucose is being fed into your system throughout the morning, thereby maintaining your energy levels.”
“In terms of our ‘energy levels’, the more modest, gradual increase in blood glucose levels, achieved by eating starchy foods (such as potatoes, bread, rice, pasta and of course porridge) is far more preferable, particularly in providing sustenance between meals and during prolonged periods of exercise.”
Wow. Do we need know more?
You are aware that I have put quote marks there, haven’t you?
I have quoted from a book of that author, whom the majority in this community (including me) thinks is biased towards ketones.
I was just stressing out why there is an obvious reason for his prejudice: he thinks porridge is a great energy source. I HOWEVER DON’T !!!!
Are we on the same page again? I agree with you, ketonian myself.