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Intermittent fasting for healthy weight loss

Intermittent fasting — introducing relatively brief but regular fasts into your eating routine — is a popular approach for weight loss and improving metabolic health. If you’re not familiar with it, you can read all about it in our beginners guide linked above.

Studies demonstrate that intermittent fasting can help people with weight loss, but there’s some controversy about whether it helps with healthy weight loss. We explain more about this distinction in our detailed guides about healthy weight loss and how to measure it. In brief, healthy weight loss involves improving metabolic health while losing mostly fat mass with minimal loss of lean muscle mass. 

See below for our top tips regarding the use of intermittent fasting for healthy weight loss. After that, read on as we examine the evidence supporting intermittent fasting for weight loss and explore whether it has been found to facilitate healthy weight loss.

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6 tips for intermittent fasting for healthy weight loss

Are there ways to use intermittent fasting to make sure you lose weight in a healthy way?

Yes! Here are our top tips:1

  1. Don’t fast for more than 24 hours at a time without professional supervision, especially if you take blood sugar lowering medications.
  2. Start with eating at least two meals per day, targeting a 14 to 18 hour fasting window.
  3. Eat an adequate-protein or high-protein diet to help maintain lean muscle mass. 
  4. Add a snack on your fasting days if needed to meet your protein goals.
  5. Add resistance training to your weekly exercise routine. 
  6. Eat until you feel satisfied — you don’t need to overeat during your eating window to “make up” for lost calories.

Intermittent fasting for weight loss

Social channels are filled with reports of significant weight loss using intermittent fasting. Studies show efficacy, too, but the reported weight loss is frequently much smaller.

One difficulty with assessing the scientific support for intermittent fasting for weight loss involves comparing different fasting protocols. For instance, some studies evaluate time-restricted eating with daily fasting windows ranging from 14 to 20 hours. Others investigate alternate-day fasting, while others focus on severe caloric restriction to mimic fasting physiology.

Another issue is factoring in the baseline diet followed by study subjects. Are many of them eating a high-carb standard Western diet? Or are they eating a low-carb, high-protein diet? The difference may matter as those eating low carb and/or high protein may find fasting easier, and thereby stick with it longer to see greater healthy weight loss benefits.

Despite the discrepancies, most fasting interventions show benefits for weight loss. (Keep reading for a few exceptions.)

One meta-analysis of randomized controlled trials (RCTs) looking at time-restricted eating (at least a 16-hour fasting window and no more than 8 hours eating each day) found an average weight loss of 4.4 pounds (2.0 kilos) in up to 12 months.2 While the absolute weight loss may not be much, that’s still pretty impressive considering that participants didn’t change what they ate. They only changed when they ate.

Other meta-analyses of intermittent fasting or severe calorie restriction (less than 800 calories per day) found greater weight loss — around 8.8 pounds (4.0 kilos) in up to 12 months — compared to a control group, and equivalent weight loss compared to continuous calorie restriction.3

So it’s safe to say that intermittent fasting has the potential to help people lose a little weight.

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Intermittent fasting for healthy weight loss

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As we’ve said, not all weight loss is the same. It’s essential to make sure you’re losing weight in a healthy way. Can intermittent fasting help with healthy weight loss?

Here, the data are conflicting.

On one hand, intermittent fasting can help improve metabolic health by reducing blood sugar and blood pressure while also improving blood lipid levels.4

On the other hand, three trials suggested that intermittent fasting may not lead to greater weight loss than usual care, or — even worse — may lead to greater loss of lean muscle mass than usual care or continuous calorie restriction.5

A healthy weight loss intervention also should be relatively easy to comply with and maintain long-term. Fortunately, intermittent fasting may fit that criteria.

One study reported that working adults found time-restricted eating with an eight-hour eating window easy to comply with and maintain for three months.6

That fits with frequent clinical experience suggesting many people easily adapt to time-restricted eating, especially when they follow a low-carb or high-protein diet that helps improve satiety and reduce appetite.7

So, in terms of convenience and ease in your approach to healthy weight loss, intermittent fasting seems to be a winner.

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Fasting for healthy weight loss – the wrap up

Intermittent fasting can play a role in your healthy weight loss lifestyle. 

But remember, fasting is not a “magic bullet.” The rest of your diet and lifestyle still matter. 

Also, remember our six tips for healthy weight loss with intermittent fasting:

  1. Start with shorter fasts, especially if you take blood sugar lowering medications. You can always increase your fasting time later as you gain experience with it.
  2. Start with eating at least two meals per day, targeting a 14 to 18 hour fasting window to ensure you aren’t feeling too deprived or excessively hungry.
  3. Eat an adequate-protein or high-protein diet to help maintain lean muscle mass.  This is a key component of healthy weight loss!
  4. If you need help meeting your protein goals, feel free to add a high-protein snack on your fasting days.
  5. It isn’t all about food. Add resistance training to your weekly exercise routine to maintain lean mass. 
  6. You don’t need to overeat during your eating window to “make up” for lost calories. Eat until you feel satisfied and then stop.

If you follow these tips, there’s a good chance that intermittent fasting can help you lose weight in a healthy way.


Intermittent fasting for healthy weight loss - the evidence

This guide is written by Dr. Bret Scher, MD and was last updated on October 3, 2022. It was medically reviewed by Dr. Michael Tamber, MD on October 3, 2022.

The guide contains scientific references. You can find these in the notes throughout the text, and click the links to read the peer-reviewed scientific papers. When appropriate we include a grading of the strength of the evidence, with a link to our policy on this. Our evidence-based guides are updated at least once per year to reflect and reference the latest science on the topic.

All our evidence-based health guides are written or reviewed by medical doctors who are experts on the topic. To stay unbiased we show no ads, sell no physical products, and take no money from the industry. We're fully funded by the people, via an optional membership. Most information at Diet Doctor is free forever.

Read more about our policies and work with evidence-based guides, nutritional controversies, our editorial team, and our medical review board.

Should you find any inaccuracy in this guide, please email andreas@dietdoctor.com.

  1. This is based on the consistent clinical experience of practitioners familiar with low-carb nutrition and intermittent fasting. [weak evidence]

  2. Journal of the Endocrine Society 2021: Effect of time-restricted feeding on body weight and cardiometabolic risks: A systematic review and meta-analysis of randomized controlled trials
    [systematic review of randomized trials; strong evidence]

    Frontiers in Nutrition 2022: Effects of intermittent fasting in human compared to a non-intervention diet and caloric restriction: A meta-analysis of randomized controlled trials
    [systematic review of randomized trials; strong evidence]

  3. JBI Database of Systematic Reviews and Implementation Reports 2018: Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis [strong evidence]

    Obesity Reviews 2017: Short‐term intermittent energy restriction interventions for weight management: a systematic review and meta‐analysis [strong evidence]

    Obesity (Silver Spring) 2016: A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity [moderate evidence]

  4. Cell Metabolism 2020: Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome [nonrandomized study; weak evidence]

    International Journal of Obesity 2011: The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women [moderate evidence]

    British Journal of Nutrition 2013: The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women [randomized trial; moderate evidence]

  5. Journal of the American Medical Association Internal Medicine 2020: Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity [randomized trial; moderate evidence]

    Science Translational Medicine 2021: A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults [randomized trial; moderate evidence]

    NEJM 2022: Calorie restriction with or without time-restricted eating in weight loss [randomized trial; moderate evidence]

  6. German Medical Science 2021: Applicability of time-restricted eating for the prevention of lifestyle-dependent diseases in a working population: results of a pilot study in a pre-post design
    [non-controlled study; weak evidence]

  7. This is based on the consistent clinical experience of practitioners familiar with low-carb nutrition and intermittent fasting. [weak evidence]