This is a fascinating new TED talk. Certain genes, when activated, make worms, flies and mice live much longer. Almost identical genes exist in humans and may have the same effect. But these genes are turned off by insulin and IGF-1.
Cynthia Keynon curiously does not mention it in this talk, but drugs and gene therapy is not the only way to get this effect. There is another simpler way and she is doing it herself. Removing excess carbs from the diet is a very effective way to lower insulin and IGF-1, activating the long-life genes.
Here is an earlier interview with her: Can cutting carbohydrates from your diet make you live longer?