Heading to Cape Town and the World’s Largest LCHF Conference

Cape Town

Cape Town

Now we’re heading for Cape Town and the world’s largest LCHF conference, that begins Thursday. It’s going to be a long flight for me and Simon Victor who’s in charge of our upcoming video reporting.

At the conference most of the world’s foremost experts on LCHF diets, weight and health are gathered. Here’s the entire list. Who would you most like to see an interview with, and about what?

22 comments

  1. eric
    Please ask about the new research that involves Beta hydroxy buterate. Also why no mention of HFLC diet as a source of ketones?

    Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer's disease.

    In their study, published in the Feb. 16 online issue of Nature Medicine, the researchers described how the compound β-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome. The inflammasome drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer's disease, atherosclerosis, and autoinflammatory disorders.

    "These findings are important because endogenous metabolites like BHB that block the NLRP3 inflammasome could be relevant against many inflammatory diseases, including those where there are mutations in the NLRP3 genes," said Vishwa Deep Dixit, professor in the Section of Comparative Medicine at Yale School of Medicine.

    BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.

    Working with mice and human immune cells, Dixit and colleagues focused on how macrophages -- specialized immune cells that produce inflammation -- respond when exposed to ketone bodies and whether that impacts the inflammasone complex.

    The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.

    "Our results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome," said Dixit.

    Other authors on the study include Yun-Hee Youm, Kim Y. Nguyen, Ryan W Grant, Emily L. Goldberg, Monica Bodogai, Dongin Kim, Dominic D'Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L. Horvath, Tarek M. Fahmy, Peter A. Crawford, Arya Biragyn, and Emad Alnemri.

    The research was funded in part by National Institutes of Health grants AI105097, AGO43608, AG031797, and DK090556.

    Replies: #2, #12
  2. Vicente
    I am also against mice eating LCHF. It is not good for them.
    Replies: #3, #7
  3. Murray
    So you must think it is not good for anyone to fast (the ultimate LCHF diet - living off fat cells).
    Reply: #5
  4. nate
    DR ANN CHILDERS M.D would be my choice. I've a close friend who is bi-polar and yet a couple of less close friends who have mental issues. I'm interest in what she has to say about helping bi-polar people and other issues with LCHF. Also, what does she think of the GAPS diet?
  5. Vicente
    Hi Murray,
    mice: plural of mouse.
    Reply: #8
  6. Jessica
    I would like to learn more about maintaining a LCHF diet during pregnancy and it's effect on mother and baby.
  7. Paul the rat
    "...It is not good for them...".
    Did mice tell you this, or it is just your wild guess?
    Reply: #11
  8. murray
    I must be a bit dopey today, Vincente. Does the "also" imply "in addition to humans" or "in addition to something else not good for mice"? or is there some problem with a group of "mice" being on LCHF as opposed to an individual "mouse"?
    Reply: #9
  9. Vicente
    Hi Murray,
    it means, "come on eric, you m.ron, don't use results obtained in mice as appliable to humans. I don't give a s.it what mice eat or what is good or bad for them. We, humans, are not mice".

    "also" means "like eric".

    That is the meaning. I can't explain it further.

  10. Paul the rat
    Here is the link to the abstract of the paper posted by eric. Thank you eric.
    Keep those ketones up folks!!

    (p.s. Vicente, please do not make ass out of yourself)

    http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3804.html

  11. Vicente
    Hi Paul,
    I really don't care about mice and their diet. That is the point.

    I remember a study where mice got NAFLD following a low-carb diet. But I cured my NAFLD thanks to a low-carb diet. I also know of a scientific study where a low-carb diet improved NAFLD in the human subjects. Results in mice are not results in humans. What if LCHF is bad for them? I don't care.

    I just wanted to point out that eric's message was not a result in humans.

    I don't understand "do not make ass out of yourself".

    Reply: #14
  12. Vicente
    Hi eric,
    I am sorry for being disrespectful to you in previous message. I shouldn't have done that.
    I wish that message was deleted.
  13. Jason Fung fan
    It would be very interesting to see an interview with Doctor Jason Fung. How did he come over intermittent fasting, what does his fellow doctors think about his methods, how many people have gotten cured through his methods,and so forth, thank you very much
    Reply: #19
  14. Murray
    Vincente, I think the value of mouse studies depends on what is being tested and whether it is a metabolic feature conserved across mammalian species into humans. For example, Dr. Cynthia Kenyon's work on the daf-2 and daf-16 genes in nematodes is conserved up to humans and so provides useful insight. The problem with mouse studies, as you advert, is that they can be manipulated. How many high-fat-diet-makes-mice-diabetic/atherosclerotic studies have seen, where it turns out the mice were fed 45% of calories as trans fats or, to stimulate appetite which is otherwise low on a high-fat diet, they are fed pure fructose syrup as a significant part of their diet. Or mice on meat, when mice are herbivores. So yes, mouse studies are rightly viewed with suspicion and critical examination to see what the study really shows. But it would be throwing the baby out with the bath water to reject mouse studies holus bolus.

    This study didn't involve an unnatural diet (adaptation to periods of fasting (high fat) is common among mammals up to humans) and the ketogenic diet seems to have been well-formulated (i.e., not 45% trans fats as in the show-fat-is-bad-rigged studies). The pathways studied are at a cellular level we can expect to be common among mammals up to humans. So I would, subject to contrary information, put a fair degree of confidence in the applicability of this study to humans.

    Replies: #15, #16
  15. Vicente
    Hi Murray,
    I am sorry for being a stupid guy yesterday.

    I get your point, and indeed I have cited experiments with mice/rats as proof that Calories In Calories Out is nonsense. I agree that sometimes those experiments are useful.

    I am trully sorry.

  16. Paul the rat
    If I may add to your eloquent paragraph Murray; the paper also describes experiments carried out using human monocytes.
  17. Bea
    I second the suggestion of an interview with Jason Jun. I've just watched his lectures on You tube and find them fascinating as well as incredibly useful (as a lay person) in understanding the obesity epidemic and how diabetes can be treated. Would love to hear more from him.
  18. eric
    Paul the rat and Murray
    Thanks for the responses.
    Sometimes a diet (LCHF) can trigger something (Ketones) that other research can lead to still more findings. Maybe a ketogenic diet triggers MCC950 protein or maybe it compliments the biologic activity. Seems like the MCC950 protein could be a marker of ketone production.??

    A team of researchers at Trinity College Dublin has unearthed what they are calling a "marvel molecule." Said to be capable of suppressing a key activator of various inflammatory diseases, it is hoped the molecule will lead to more effective treatments for conditions ranging from Alzheimer’s disease, to rheumatoid arthritis and motor neuron disease.

    The massive potential of the molecule lies in its ability to block a key activator of inflammatory diseases known as the NLRP3 inflammasome. Inflammasomes, protein clusters responsible for triggering a range of inflammatory processes, have long been considered potential therapeutic targets for treating a range of conditions.

    Through the study, the researchers found the molecule, dubbed MCC950, to be very promising in warding off multiple sclerosis. But what really pleased the researchers was the fact that the target, the NLRP3 inflammasome, also plays a strong role in the onset of other inflammatory diseases including Alzheimer’s, atherosclerosis, gout and Parkinson's disease.

    "MCC950 is blocking what was suspected to be a key process in inflammation," says Dr Rebecca Coll, lead author of the paper. "There is huge interest in NLRP3 both among medical researchers and pharmaceutical companies and we feel our work makes a significant contribution to the efforts to find new medicines to limit it."

    The findings are said to confirm that while different inflammatory conditions may cause different parts of the body to become inflamed, the diseases all share a common process. This has the potential to spawn new kinds of cheaper, non-invasive treatments for inflammatory diseases.

    "MCC950 is able to be given orally and will be cheaper to produce than current protein-based treatments, which are given daily, weekly, or monthly by injection," says Professor Matt Cooper from the University of Queensland, a co-senior author of the study. "Importantly, it will also have a shorter duration in the body, allowing clinicians to stop the anti-inflammatory action of the drug if the patient ever needed to switch their immune response back to 100 percent in order to clear an infection.”

    The researchers say that the molecule may also benefit sufferers of Muckle-Wells disease, a rare genetic disorder that can cause rashes, joint pain and other inflammations. Treating blood samples of patients with Muckle-Wells disease, the molecule was shown to block the rogue gene that triggers these recurring inflammatory processes.

    "We are really excited about MCC950," says Professor of Biochemistry at Trinity College Dublin and joint senior scientist behind the discovery. "We believe this has real potential to benefit patients suffering from several highly debilitating diseases, where there is currently a dire need for new medicines."

    The research was published in the journal Nature.

    Source: Trinity College Dublin

  19. Apicius
    Agreed! I would like to see an interview with Dr Jason Fung, too! His clinic in Toronto, Canada is showing success.
  20. Mahima
    I would like to ask Dr Aseem Malhotra (since he's the only Indian Doctor in the list), if they could throw some light on the LCHF / Ketogenic diet from an Indian point of view. A lot of things like kale, Brussels sprouts, avocados, free range organic meats etc are not available here, and maybe he could give us a list of INDIAN things to eat and things to avoid.

    Also I want to know the view of most doctors on full fat cream and cheese. I know diet doctor allows cream and cheese, but some people say you can't keto adapt with cream or cheese. The diet becomes very tough and very bland/boring without cream and cheese.

    Thanks!

    Reply: #21
  21. Murray
    Mahima, I have cheese every day (mostly raw sheep milk cheeses) and my ketones average about 2.0 mmol/L every morning, even higher if I do a long walk in the evening after dinner. I also have cream but not daily. In my experience, tolerance for cheese and cream depends on on how much you are having and on what else you are eating. Uncultured cream has some sugar and also has whey protein. Whey protein seems to stimulate insulin more than other proteins. (Most cheeses drain off whey. When the milk ferments, the acid (such as lactic or propionic) produced by the bacteria, with the rennet, cause the casein molecules than "encase" minerals to form a web and entrap fat globules (to form curds) and the whey mostly drains off.) Insulin drives down ketones, so any big protein meal will trigger insulin to drive down ketones. That is why a ketogenic diet is a modest protein diet and not a big protein diet. (Journalists and dieticians often mischaracterize a ketogenic diet as a high protein diet.) So whether you can have cheese and cream and stay in ketosis will depend on how much carbs and how much other protein you are eating. That said, some people seem to have difficulty with dairy. Happily, I am not one of them.
    Reply: #22
  22. erdoke
    I fully agree with your assessment, Murray. Maybe it is also worth noting that on top of high fat content, organic acids and fibers tend to decrease the insulin raising effect of other food types. A bit higher red meat and whey can be allowed if these are added. It means sour and fermented things are usually our friends. In fact I contribute much of the beneficial effect of daily moderate wine consumption to the organic acids and not to the low level of phytochemicals and definitely not to the alcohol.

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