Working hard

We have big plans for January here at So if there are fewer posts than usual over the next two weeks it’s because we’re working hard on something exciting that you’ll get to see soon. And also, Christmas.


  1. Paul TR
    We do not have to restrict calories to produce ketones- just do LCHF

    Front Aging Neurosci. 2015 Nov 13;7:213. doi: 10.3389/fnagi.2015.00213. eCollection 2015.
    Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice.
    Guo J1, Bakshi V1, Lin AL2.
    Author information

    Preservation of brain integrity with age is highly associated with lifespan determination. Caloric restriction (CR) has been shown to increase longevity and healthspan in various species; however, its effects on preserving living brain functions in aging remain largely unexplored. In the study, we used multimodal, non-invasive neuroimaging (PET/MRI/MRS) to determine in vivo brain glucose metabolism, energy metabolites, and white matter structural integrity in young and old mice fed with either control or 40% CR diet. In addition, we determined the animals' memory and learning ability with behavioral assessments. Blood glucose, blood ketone bodies, and body weight were also measured. We found distinct patterns between normal aging and CR aging on brain functions - normal aging showed reductions in brain glucose metabolism, white matter integrity, and long-term memory, resembling human brain aging. CR aging, in contrast, displayed an early shift from glucose to ketone bodies metabolism, which was associated with preservations of brain energy production, white matter integrity, and long-term memory in aging mice. Among all the mice, we found a positive correlation between blood glucose level and body weight, but an inverse association between blood glucose level and lifespan. Our findings suggest that CR could slow down brain aging, in part due to the early shift of energy metabolism caused by lower caloric intake, and we were able to identify the age-dependent effects of CR non-invasively using neuroimaging. These results provide a rationale for CR-induced sustenance of brain health with extended longevity.

    Reply: #2
  2. Nate
    Paul thanks for the abstract about calorie restriction and aging and also your comment about it. I wonder why the authors did not at least mention the possible significance of metabolizing ketones instead of glucose for brain health. I wonder if it is the popularity of the myth that the body's, as well as the brain's, main fuel is glucose.

    My pet theory is that glucose is preferentially burned first because those bodies that did that evolved better than others. Taking that a step further, I wonder if someone fed, say, chimps much more fatty meat that they would over generations live longer and get smarter. Or for that matter, try it with rats.

  3. Pierre
    "The principle ketones include acetoacetate (AcAc), β-hydroxybutyrate (BHB) and ace-tone. In times of starvation and low insulin levels, ketones supply up to 50% of basal energy requirements for most tissues, and up to 70% for the brain. Although glucose is the main metabolic substrate for neurons, ketones are capable of fulfilling the energy requirements of the brain."

    Happy Christmas Andreas, family and friends. Thanks for the continued, brave work that has helped my health immensely.
    Reply: #5
  5. Dr. Andreas Eenfeldt, MD Team Diet Doctor
    Thanks, and Happy Christmas!
  6. Adrian
    So what are the plans Andreas? Can you give us a hint? I'm excited!

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