Campaign to Have “Paleo” Mouse Study Retracted

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The Paleo Diet Explained – Professor Loren Cordain
LCHF Paleo – Mark Sisson

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New Study Claims Paleo Diet Causes Diabetes and Obesity, for People Who Are Mice

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6 Comments

  1. Pierre
    Actually, the guy who wrote that fable should be fired.
  2. George Henderson (@puddleg)
    I put this response on a website about the study

    The study was supposed to answer a question that is of great importance in diabetes research
    - the blood sugars of people with diabetes almost always improve and can become completely normal on the LCHF diet - this is actually something that has been known for a century or more
    - if you challenge someone who is doing well on the LCHF diet with an oral glucose tolerance test (a sudden large carbohydrate load) their response is often poor
    - is this a physiological adaptation to the diet, or does it indicate a risk of beta cell deterioration (as is usually seen long-term when high carb diets are fed to people with type 2 diabetes)?

    The problem with the study, with regard to this question, is
    1) that the mice chosen had a genetic defect, one that has never occurred in humans, which makes them fat-intolerant.
    2) the NZO LCHFD rats gained weight significantly, whereas most overweight humans lose weight on the LCHFD and it is very rare to gain a significant amount of fat mass.
    Weight is an important determinant of insulin resistance and glycemic control.
    3) there was no difference in beta-cell morphology in the LCHFD NZO rats despite their weight gain and insulin resistance.
    4) the diets were in no way designed to test the Paleo premise, which is that specific Neolithic and refined and processed modern foods have deleterious effects on the human organism, including with regard to weight and glycemic control.

    Thus the study was inconclusive on its own terms, and could shed little light on the effect of a LCHFD in humans, and press releases equating its results to the probable effect of a LCHF or a Paleo diet (2 different things) were wholly unjustified.
    These remarks and the wide publicity they received amount to unjustified interference in diabetes treatment methods that are working well.

    More detail on Grant Schofield's blog here: http://profgrant.com/2016/02/20/the-most-famous-new-zealand-mice-in-t...

  3. Christine H
    Responses to this have all been amongst the enlightened on social media so far as I can tell. I am deafened by the silence from our mainstream health journalists ( I am from Western Australia) and sadly have seen no commentary from our health journo crowd.
  4. Tim R
    In other news, the Rats of Nimh completed an eating study where feeding humans grain products induce dramatic weight gain. They have concluded that rodents should immediately adopt the Paleo diet.
    Reply: #5
  5. Apicius
    That's funny, Tim R!!!! Hahahahaha!
  6. 1 comment removed
  7. Leroy
    I find it both ridiculous and fraudulent.

    Every bit as much as the fictitious "Okinawan Diet" and "Mediterranean Diet" that are getting promoted on mainstream media again... just the morning on one of those shows that has several women sitting around talking (with one of the topics always "health". Right after their female expert nutritionist proclaimed that bread - as long as whole grain - was neither unhealthy or fattening, she proceeded to laud the benefits of the "Mediterranean Diet" (sic) and how it is making a HUGE comeback.

    And as bad as the Mediterranean Diet and Okinawan Diet actually are, the facts is that they are FRAUDULENT... that is not even how those people eat or ever ate.

    But the exact same can be said for the "Victorian Era Diet". It is NOT healthy. It never existed in the concept promoted with ANY of the classes of Victorian Era England. And it is NOT remotely a Paleolithic Diet, not a generic Low Carb diet, much less LCHF. It should be just as adamantly condemned.

    And yet this site published it in a positive light with a pro attitude - in what amounted to simply free publicity for the author who INVENTED this diet and what would appear to many people as an "endorsement" of that (unhealthy, non LCHF) fictional diet.

    Where's the campaign to remove it?

    I tried a "letter to the editor" and was blown off with a (very brief) response that was ridiculously unresponsive.

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